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Version: 17.06d (Release date: 2017-06-26)
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Vaccinia Virus DD-CDSR (Code C74089)

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Terms & Properties

Preferred Name: Vaccinia Virus DD-CDSR

Definition: A highly tumor-selective vaccinia virus (vv) with an engineered double deletion (DD) of the thymidine kinase (tk) and vaccinia growth factor genes and additions of both a cytosine deaminase (CD) gene and a somatostatin receptor (SR) gene with potential oncolytic viral activity. The tk and vaccinia growth factor gene deletions in intratumorally administered vaccinia virus (vvDD-CDSR) help to restrict its replication and cytolytic activity to tumor cells with large nucleotide pools and tumor cells with activation of the EGFR-Ras pathway. Addition of the CD gene to the viral genome allows control of oncolytic viral infection through the administration of the prodrug 5-fluorocytosine (5-FC), converted by CD to the antimetabolite 5-fluorouracil (5-FU) in cells infected with this agent. Addition of the SR gene allows anatomical localization of vaccinia virus (vvDD-CDSR) through the use of octreotide scintigraphy.

Display Name: Vaccinia Virus DD-CDSR

Label: Vaccinia Virus DD-CDSR

NCI Thesaurus Code: C74089 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL384004  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Vaccinia Virus (vvDD-CDSR)
Vaccinia Virus DD-CDSR
vvDD-CDSR

External Source Codes: 
PDQ Closed Trial Search ID 583659
PDQ Open Trial Search ID 583659 (check for NCI PDQ open clinical trial info)
NCI META CUI CL384004

Other Properties:
     Name Value (qualifiers indented underneath)
code C74089
Contributing_Source CTRP
Legacy_Concept_Name Vaccinia_virus_DD-CDSR_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74089

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