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Version: 16.11d (Release date: 2016-11-28)
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Udenafil (Code C74086)

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Terms & Properties

Preferred Name: Udenafil

Definition: A benzenesulfonamide derivative with vasodilatory activity. Udenafil selectively inhibits phosphodiesterase type 5 (PDE5), thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis; inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. This agent does not significantly inhibit the PDE11 isozyme; PDE11 inhibition may be associated with significant myalgia.

Label: Udenafil

NCI Thesaurus Code: C74086 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1742789  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-(1-methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-{2-[(2RS)-1-methylpyrrolidin-2-yl]ethyl}-4-propoxybenzenesulfonamide
Benzenesulfonamide, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxy-
DA-8159
UDENAFIL
Udenafil
Zydena

External Source Codes: 
CAS Registry Number 268203-93-6 (see NLM ChemIDplus info)
FDA UNII Code L5IB4XLY36
PDQ Closed Trial Search ID 588896
PDQ Open Trial Search ID 588896 (check for NCI PDQ open clinical trial info)
UMLS CUI C1742789

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For erectile dysfunction
Chemical_Formula C25H36N6O4S
code C74086
Contributing_Source FDA
Legacy_Concept_Name Udenafil
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74086

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