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Version: 16.11d (Release date: 2016-11-28)
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TLR9 Agonist IMO-2055 (Code C74083)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: TLR9 Agonist IMO-2055

Definition: A synthetic oligonucleotide containing unmethylated CpG dinucleotides with potential immunopotentiating activity. Mimicking unmethylated CpG sequences in bacterial DNA, TLR9 agonist IMO-2055 binds to and activates intracellular Toll-like receptors (TLR) 9 in monocytes/macrophages, plasmacytoid dendritic cells (DCs) and B cells, initiating immune signaling pathways and activating B cells and DCs and inducing T-helper cell cytokine production. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity.

Display Name: TLR9 Agonist IMO-2055

Label: TLR9 Agonist IMO-2055

NCI Thesaurus Code: C74083 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL448927  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IMO-2055
TLR9 Agonist IMO-2055

External Source Codes: 
PDQ Closed Trial Search ID 592510
PDQ Open Trial Search ID 592510 (check for NCI PDQ open clinical trial info)
NCI META CUI CL448927

Other Properties:
Name Value (qualifiers indented underneath)
code C74083
Contributing_Source CTRP
Legacy_Concept_Name TLR9_Agonist_IMO-2055
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74083

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