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Version: 17.06d (Release date: 2017-06-26)
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Thioredoxin-1 Inhibitor PX-12 (Code C74082)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Thioredoxin-1 Inhibitor PX-12

Definition: An orally bioavailable small molecule with potential antineoplastic activity. Thioredoxin-1 inhibitor PX-12 irreversibly binds to thioredoxin-1 (Trx-1) and inhibits its activity, which may result in growth inhibition and the induction of apoptosis. Overexpressed in many cancer cell types, the low molecular weight redox protein Trx-1 regulates transcription factor activity and inhibits apoptosis, promoting cell growth and survival; it also interacts with growth factors extracellularly to stimulate cell growth.

Display Name: Thioredoxin-1 Inhibitor PX-12

Label: Thioredoxin-1 Inhibitor PX-12

NCI Thesaurus Code: C74082 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0960559  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-Methylpropyl 2-Imidazolyl Disulfide
PX-12
Thioredoxin-1 Inhibitor PX-12

External Source Codes: 
PDQ Closed Trial Search ID 590656
PDQ Open Trial Search ID 590656 (check for NCI PDQ open clinical trial info)
UMLS CUI C0960559

Other Properties:
     Name Value (qualifiers indented underneath)
code C74082
Contributing_Source CTRP
Legacy_Concept_Name Thioredoxin-1_Inhibitor_PX-12
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74082

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