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Version: 17.06d (Release date: 2017-06-26)
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Testosterone Gel (Code C74081)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Testosterone Gel

Definition: A topical gel preparation of synthetic testosterone. In vivo, testosterone is irreversibly converted to dihydrotestosterone (DHT) in target tissues by the enzyme 5-alpha reductase. Testosterone or DHT ligand-androgen receptor complexes act as transcription factor complexes, stimulating the expression of various responsive genes, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus; DHT binds with higher affinity to nuclear androgen receptors than testosterone. In addition, testosterone is irreversibly converted to estradiol by the enzyme complex aromatase, particularly in the liver and adipose tissue. Testosterone and DHT promote the development and maintenance of male sex characteristics related to the internal and external genitalia, skeletal muscle, and hair follicles; estradiol promotes epiphyseal maturation and bone mineralization.

Display Name: Testosterone Gel

Label: Testosterone Gel

NCI Thesaurus Code: C74081 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0875960  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AndroGel
Fortesta
Testosterone Gel

External Source Codes: 
PDQ Closed Trial Search ID 589197
PDQ Open Trial Search ID 589197 (check for NCI PDQ open clinical trial info)
UMLS CUI C0875960

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hypogonadism -- Male
code C74081
Contributing_Source CTRP
Legacy_Concept_Name Testosterone_Gel
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74081

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