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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Src Kinase Inhibitor KX2-391 (Code C74077)

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Terms & Properties

Preferred Name: Src Kinase Inhibitor KX2-391

Definition: An orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to the ATP-binding site, Src kinase inhibitor KX2-391 specifically binds to the peptide substrate binding site of Src kinase; inhibition of kinase activity may result in the inhibition of primary tumor growth and the suppression of metastasis. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation and metastasis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. KX2-391 blocks an enzyme needed for growth of cells and may kill cancer cells. It is a type of Src kinase inhibitor.

Display Name: Src Kinase Inhibitor KX2-391

Label: Src Kinase Inhibitor KX2-391

NCI Thesaurus Code: C74077 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348411  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Src Kinase Inhibitor KX2-391

External Source Codes: 
PDQ Closed Trial Search ID 590687
PDQ Open Trial Search ID 590687 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348411

Other Properties:
     Name Value (qualifiers indented underneath)
code C74077
Contributing_Source CTRP
Legacy_Concept_Name Src_Kinase_Inhibitor_KX2-391
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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