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Version: 17.12d (Release date: 2017-12-26)
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Rexinoid NRX 194204 (Code C74076)

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Terms & Properties

Preferred Name: Rexinoid NRX 194204

Definition: An orally bioavailable synthetic retinoid X receptor (RXR) agonist with potential antineoplastic and anti-inflammatory activities. Rexinoid NRX 194204 selectively binds to and activates RXRs. Because RXRs can form heterodimers with several nuclear receptors (NRs), RXR activation by this agent may result in a broad range of gene expression depending on the effector DNA response elements activated. Rexinoid NRX 194204 may inhibit the tumor-necrosis factor (TNF)-mediated release of nitric oxide (NO) and interleukin 6 (IL6) and may inhibit tumor cell proliferation. This agent appears to be less toxic than RAR-selective ligands.

Display Name: Rexinoid NRX 194204

Label: Rexinoid NRX 194204

NCI Thesaurus Code: C74076 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0967787  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Rexinoid NRX 194204

External Source Codes: 
CAS Registry Number 260262-39-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 592353
PDQ Open Trial Search ID 592353 (check for NCI PDQ open clinical trial info)
UMLS CUI C0967787

Other Properties:
     Name Value (qualifiers indented underneath)
code C74076
Contributing_Source CTRP
Legacy_Concept_Name Rexinoid_NRX_194204
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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