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Version: 17.06d (Release date: 2017-06-26)
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PI3K Inhibitor BGT226 (Code C74073)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PI3K Inhibitor BGT226

Definition: A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BGT226 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability; apoptotic cell death may ensue. Bax is a member of the proapoptotic Bcl2 family of proteins.

Display Name: PI3K Inhibitor BGT226

Label: PI3K Inhibitor BGT226

NCI Thesaurus Code: C74073 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2347426  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BGT226
PI3K Inhibitor BGT226

External Source Codes: 
PDQ Closed Trial Search ID 587478
PDQ Open Trial Search ID 587478 (check for NCI PDQ open clinical trial info)
UMLS CUI C2347426

Other Properties:
     Name Value (qualifiers indented underneath)
code C74073
Contributing_Source CTRP
Legacy_Concept_Name PI3K_Inhibitor_BGT226
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74073

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