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Version: 16.10e (Release date: 2016-10-31)
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PI3K/mTOR Inhibitor BEZ235 (Code C74072)

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Terms & Properties

Preferred Name: PI3K/mTOR Inhibitor BEZ235

Definition: An orally bioavailable imidazoquinoline targeting the phosphatidylinositol 3 kinase (PI3K) and the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PI3K/mTOR inhibitor BEZ235 inhibits PI3K kinase and mTOR kinase in the PI3K/AKT/mTOR kinase signaling pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K/mTOR-overexpressing tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.

Display Name: PI3K/mTOR Inhibitor BEZ235

Label: PI3K/mTOR Inhibitor BEZ235

NCI Thesaurus Code: C74072 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2604817  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BEZ235
PI3K/mTOR Inhibitor BEZ235

External Source Codes: 
PDQ Closed Trial Search ID 589292
PDQ Open Trial Search ID 589292 (check for NCI PDQ open clinical trial info)
UMLS CUI C2604817

Other Properties:
Name Value (qualifiers indented underneath)
code C74072
Contributing_Source CTRP
Legacy_Concept_Name PI3K_Inhibitor_BEZ235
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74072

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