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Version: 17.06d (Release date: 2017-06-26)
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Parathyroid Hormone-Related Protein (1-36) (Code C74068)

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Terms & Properties

Preferred Name: Parathyroid Hormone-Related Protein (1-36)

Definition: A recombinant form of a mature, N-terminal secretory peptide derived from a parathyroid hormone-related protein (PTHrP) preprohormone through posttranslational endoproteolytic processing with vasodilating, myorelaxant, and parathyroid hormone (PTH)-like calciotropic activities. Expressed throughout the cardiovascular system, parathyroid hormone-related protein (1-36) [PTHrP (1-36)] was first identified as the PTH-like hypercalcemic factor of humoral hypercalcemia of malignancy; however, its sequence differs significantly from that of PTH (1-34) although both proteins share the same N-terminal end which accounts for the calciotropic activity. Both PTHrP (1-36) and PTH (1-34) bind to the type 1 parathyroid hormone receptor (PTH1R), a specific seven-transmembrane-helix-containing G protein-coupled receptor mainly located in bone and kidney cells.

Label: Parathyroid Hormone-Related Protein (1-36)

NCI Thesaurus Code: C74068 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0213895  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Parathyroid Hormone-Related Protein (1-36)
PTHrP (1-36)

External Source Codes: 
PDQ Closed Trial Search ID 585556
PDQ Open Trial Search ID 585556 (check for NCI PDQ open clinical trial info)
UMLS CUI C0213895

Other Properties:
     Name Value (qualifiers indented underneath)
code C74068
Legacy_Concept_Name Parathyroid_Hormone-Related_Protein_1-36_Peptide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74068

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