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Version: 17.08d (Release date: 2017-08-28)
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Oncolytic Adenovirus Ad5-DNX-2401 (Code C74067)

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Terms & Properties

Preferred Name: Oncolytic Adenovirus Ad5-DNX-2401

Definition: An adenovirus serotype 5 strain, selectively replication competent in cells defective in the Rb/p16 tumor suppressor pathway, with potential oncolytic activity. Oncolytic adenovirus Ad5-DNX2401 contains an integrin binding RGD-4C motif, allowing Coxsackie adenovirus receptor-independent infection of tumor cells, which are often deficient for Coxsackie and adenovirus receptors (CARs). Selectively replication competent in cells that are defective in retinoblastoma gene (Rb) or cyclin-dependent kinase inhibitor-2A (p16), active replication of oncolytic adenovirus Ad5-Delta 24RGD in tumor cells may induce oncolysis or cell lysis. As integral components of the late G1 restriction point, the Rb gene product and p16 are negative regulators of the cell cycle; ovarian cancer cells and non-small cell lung cancer cells may be defective in the Rb/p16 pathway.

Display Name: Oncolytic Adenovirus Ad5-DNX-2401

Label: Oncolytic Adenovirus Ad5-DNX-2401

NCI Thesaurus Code: C74067 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383850  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Oncolytic Ad5-Delta 24RGD
Oncolytic Adenovirus Ad5-Delta 24RGD
Oncolytic Adenovirus Ad5-DNX-2401

External Source Codes: 
PDQ Closed Trial Search ID 590711
PDQ Open Trial Search ID 590711 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C74067
Contributing_Source CTRP
Legacy_Concept_Name Oncolytic_Ad5-Delta_24RGD
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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