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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Nanoparticle Albumin-Bound Rapamycin (Code C74065)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nanoparticle Albumin-Bound Rapamycin

Definition: The macrolide antibiotic rapamycin bound to nanoparticle albumin with immunosuppressant (see sirolimus) and potential antiangiogenic and antineoplastic activities. Rapamycin binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate a complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. In turn, inhibition of mTOR may result in the inhibition of the phosphatidylinositol 3 (PI-3) kinase/Akt pathway and vascular endothelial cell growth factor (VEGF) secretion, which may result in decreased tumor cell proliferation and tumor angiogenesis. The binding of water-insoluble rapamycin to nanoparticle albumin permits the albumin-mediated endocytosis of rapamycin by tumor cells and endothelial cells.

Display Name: Nanoparticle Albumin-Bound Rapamycin

Label: Nanoparticle Albumin-Bound Rapamycin

NCI Thesaurus Code: C74065 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383470  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABI-009
Nab-Rapamycin
Nanoparticle Albumin-Bound Rapamycin

External Source Codes: 
PDQ Closed Trial Search ID 583541
PDQ Open Trial Search ID 583541 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383470

Other Properties:
     Name Value (qualifiers indented underneath)
code C74065
Contributing_Source CTRP
Legacy_Concept_Name Nanoparticle_Albumin-Bound_Rapamycin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74065

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