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Version: 17.06d (Release date: 2017-06-26)
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Mixed Bacteria Vaccine (Code C74063)

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Terms & Properties

Preferred Name: Mixed Bacteria Vaccine

Definition: A cancer vaccine containing a mixture of killed bacteria with potential immunostimulatory and antineoplastic activities. Mixed bacteria vaccine (MBV or Coley's toxins) consists of a pyrogenic bacterial lysate derived from Serratia marcescens and Streptococcus pyogenes; the active components in the lysate may be lipopolysaccharide (LPS), a component of the Gram-negative bacterial cell wall of Serratia, and streptokinase, an enzyme produced by Streptococcus pyogenes. LPS has been shown to stimulate the host humoral immune response and induce the release of various antitumor cytokines such as tumor necrosis factor (TNF) and interleukin-12 (IL-12).

Label: Mixed Bacteria Vaccine

NCI Thesaurus Code: C74063 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383537  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Coley's Toxin
MBV
Mixed Bacteria Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 590146
PDQ Open Trial Search ID 590146 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383537

Other Properties:
     Name Value (qualifiers indented underneath)
code C74063
Legacy_Concept_Name Mixed_Bacteria_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74063

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