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Version: 17.06d (Release date: 2017-06-26)
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MET Tyrosine Kinase Inhibitor SGX523 (Code C74062)

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Terms & Properties

Preferred Name: MET Tyrosine Kinase Inhibitor SGX523

Definition: An orally bioavailable small molecule, c-Met inhibitor with potential antineoplastic activity. MET receptor tyrosine kinase inhibitor SGX523 specifically binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.

Label: MET Tyrosine Kinase Inhibitor SGX523

NCI Thesaurus Code: C74062 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346913  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MET Tyrosine Kinase Inhibitor SGX523

External Source Codes: 
PDQ Closed Trial Search ID 588972
PDQ Open Trial Search ID 588972 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346913

Other Properties:
     Name Value (qualifiers indented underneath)
code C74062
Legacy_Concept_Name MET_Tyrosine_Kinase_Inhibitor_SGX523
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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