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Version: 17.06d (Release date: 2017-06-26)
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Crizotinib (Code C74061)

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Terms & Properties

Preferred Name: Crizotinib

Definition: An orally available aminopyridine-based inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the c-Met/hepatocyte growth factor receptor (HGFR) with antineoplastic activity. Crizotinib, in an ATP-competitive manner, binds to and inhibits ALK kinase and ALK fusion proteins. In addition, crizotinib inhibits c-Met kinase, and disrupts the c-Met signaling pathway. Altogether, this agent inhibits tumor cell growth. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.

NCI-GLOSS Definition: A substance being studied in the treatment of some types of cancer. It blocks enzymes that cancer cells need to grow and spread. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.

Display Name: Crizotinib

Label: Crizotinib

NCI Thesaurus Code: C74061 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2974289  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(R)-3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-5-(1-(Piperidin-4-Yl)-1h-Pyrazol-4-Yl)Pyridin-2-Amine
2-Pyridinamine, 3-((1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-5-(1-(4-Piperidinyl)-1H-Pyrazol-4-yl)-
Crizotinib
CRIZOTINIB
MET tyrosine kinase inhibitor PF-02341066
MET Tyrosine Kinase Inhibitor PF-02341066
PF-02341066
PF-2341066
Xalkori

External Source Codes: 
CAS Registry Number 877399-52-5 (see NLM ChemIDplus info)
FDA UNII Code 53AH36668S
ChEBI ID CHEBI:64310 (see ChEBI info)
PDQ Closed Trial Search ID 586080
PDQ Open Trial Search ID 586080 (check for NCI PDQ open clinical trial info)
UMLS CUI C2974289

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Non-Small Cell Lung Cancer
Chemical_Formula C21H22Cl2FN5O
code C74061
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name MET_Tyrosine_Kinase_Inhibitor_PF-02341066
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74061

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