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Version: 17.06d (Release date: 2017-06-26)
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MET Tyrosine Kinase Inhibitor BMS-777607 (Code C74060)

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Terms & Properties

Preferred Name: MET Tyrosine Kinase Inhibitor BMS-777607

Definition: An inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.

Label: MET Tyrosine Kinase Inhibitor BMS-777607

NCI Thesaurus Code: C74060 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346911  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-777607
MET Tyrosine Kinase Inhibitor BMS-777607

External Source Codes: 
PDQ Closed Trial Search ID 587999
PDQ Open Trial Search ID 587999 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346911

Other Properties:
     Name Value (qualifiers indented underneath)
code C74060
Legacy_Concept_Name MET_Tyrosine_Kinase_Inhibitor_BMS-777607
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74060

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