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Version: 17.06d (Release date: 2017-06-26)
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Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207 (Code C74055)

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Terms & Properties

Preferred Name: Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207

Definition: A recombinant Listeria-based cancer vaccine containing a live-attenuated strain of the facultative intracellular bacterium Listeria monocytogenes (Lm) expressing human mesothelin with potential immunostimulatory and antineoplastic activities. Upon administration of this vaccine, Listeria invade professional phagocytes within the immune system and express mesothelin, which may activate a cytotoxic T-lymphocyte (CTL) response against mesothelin-expressing tumor cells, resulting in tumor cell lysis. In addition, the Listeria vector itself may induce a potent innate and adaptive immunity unrelated to mesothelin expression. Mesothelin is a cell surface glycoprotein involved in cell adhesion and is overexpressed in many epithelial-derived cancers, including pancreatic, ovarian and lung cancers, and malignant mesotheliomas.

Display Name: Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207

Label: Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207

NCI Thesaurus Code: C74055 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383482  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CRS-207
LADD Listeria monocytogenes CRS-207
Live-Attenuated Listeria Encoding Human Mesothelin Vaccine CRS-207

External Source Codes: 
PDQ Closed Trial Search ID 586104
PDQ Open Trial Search ID 586104 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383482

Other Properties:
     Name Value (qualifiers indented underneath)
code C74055
Contributing_Source CTRP
Legacy_Concept_Name Live-Attenuated_Listeria_Encoding_Human_Mesothelin_Vaccine_CRS-207
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74055

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