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Version: 16.11d (Release date: 2016-11-28)
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Iodine I 125-Anti-EGFR-425 Monoclonal Antibody (Code C74051)

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Terms & Properties

Preferred Name: Iodine I 125-Anti-EGFR-425 Monoclonal Antibody

Definition: A radioimmunoconjugate consisting of a murine IgG2a monoclonal antibody directed against the human epidermal growth factor receptor (EGFR) labeled with iodine I 125 with potential antineoplastic activity. Iodine I 125 anti-EGFR-425 monoclonal antibody binds specifically to the epidermal growth factor receptor (EGFR). Upon binding to EGFR-expressing tumor cells, this agent is internalized, selectively delivering a potentially cytotoxic dose of gamma radiation. EGFR is a receptor tyrosine kinase that may be overexpressed on the cell surfaces of various solid tumors.

Label: Iodine I 125-Anti-EGFR-425 Monoclonal Antibody

NCI Thesaurus Code: C74051 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383810  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Iodine I 125-Anti-EGFR-425 Monoclonal Antibody

External Source Codes: 
PDQ Closed Trial Search ID 586304
PDQ Open Trial Search ID 586304 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383810

Other Properties:
Name Value (qualifiers indented underneath)
code C74051
Legacy_Concept_Name Iodine_I_125-Anti-EGFR-425_Monoclonal_Antibody
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74051

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