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Version: 17.06d (Release date: 2017-06-26)
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Dual IGF-1R/InsR Inhibitor BMS-754807 (Code C74043)

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Terms & Properties

Preferred Name: Dual IGF-1R/InsR Inhibitor BMS-754807

Definition: An oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity. Dual IGF-IR/InsR inhibitor BMS-754807 binds reversibly to and inhibits the activities of IGF-1R and InsR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R and InsR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in mitogenesis, angiogenesis, and tumor cell survival.

Display Name: Dual IGF-1R/InsR Inhibitor BMS-754807

Label: Dual IGF-1R/InsR Inhibitor BMS-754807

NCI Thesaurus Code: C74043 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346450  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BMS-754807
Dual IGF-1R/InsR Inhibitor BMS-754807

External Source Codes: 
CAS Registry Number 1001350-96-4 (see NLM ChemIDplus info)
FDA UNII Code W9E3353E8J
PDQ Closed Trial Search ID 583260
PDQ Open Trial Search ID 583260 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346450

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C23H26FN9O
code C74043
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name IGF1R_Antagonist_BMS-754807
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74043

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