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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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huBC1-huIL12 Fusion Protein AS1409 (Code C74041)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: huBC1-huIL12 Fusion Protein AS1409

Definition: An immunoconjugate consisting of the anti-tumor cytokine interleukin-12 (IL-12) fused to the tumor-targeting antibody BC1 with potential immunostimulatory and antineoplastic activities. The antibody moiety of huBC1-huIL12 fusion protein AS1409 binds to the human fibronectin splice variant ED-B, delivering IL-12 directly to the tumor vasculature; tumor vasculature-targeted IL-12 initiates localized immune cascade responses and exhibits cytotoxic and anti-angiogenic activity while minimizing the systemic side effects of IL-12. The human fibronectin splice variant ED-B is over-expressed in the extracellular matrix and blood vessels of tumor tissues.

Label: huBC1-huIL12 Fusion Protein AS1409

NCI Thesaurus Code: C74041 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383540  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
huBC1-huIL12 Fusion Protein AS1409

External Source Codes: 
PDQ Closed Trial Search ID 590612
PDQ Open Trial Search ID 590612 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C74041
Legacy_Concept_Name huBC1-huIL12_Fusion_Protein_AS1409
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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