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Version: 16.10e (Release date: 2016-10-31)
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HLA-A*2402-Restricted URLC10-TTK-VEGFR1-VEGFR2 Multipeptide Vaccine (Code C74039)

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Terms & Properties

Preferred Name: HLA-A*2402-Restricted URLC10-TTK-VEGFR1-VEGFR2 Multipeptide Vaccine

Definition: A cancer vacine containing four HLA-A*2402-restricted peptide epitopes with potential immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived from: URLC10 (up-regulated lung cancer 10), TTK (TTK protein kinase), and VEGFRs (vascular endothelial growth factor receptors) 1 and 2. Upon administration, URLC10-TTK-KOC1-VEGFR1-VEGFR2 multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing URLC10, TTK, VEGFR 1 and 2 peptides, resulting in cell lysis and decreased tumor growth. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve antigenic peptide immunogenicity.

Label: HLA-A*2402-Restricted URLC10-TTK-VEGFR1-VEGFR2 Multipeptide Vaccine

NCI Thesaurus Code: C74039 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383552  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HLA-A*2402-Restricted URLC10-TTK-VEGFR1-VEGFR2 Multipeptide Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 592511
PDQ Open Trial Search ID 592511 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383552

Other Properties:
Name Value (qualifiers indented underneath)
code C74039
Legacy_Concept_Name HLA-A_2402-Restricted_URLC10-TTK-VEGFR1-VEGFR2_Multipeptide_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74039

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