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Version: 17.06d (Release date: 2017-06-26)
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Vismodegib (Code C74038)

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Terms & Properties

Preferred Name: Vismodegib

Definition: An orally bioavailable small molecule with potential antineoplastic activity. Hedgehog antagonist GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks a type of protein involved in tissue growth and repair and may block the growth of cancer cells. It is a type of Hedgehog signaling pathway antagonist.

Display Name: Vismodegib

Label: Vismodegib

NCI Thesaurus Code: C74038 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348949  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-chloro-N-[4-chloro-3-(pyridin-2-yl)phenyl]-4-(methylsulfonyl)benzamide
Erivedge
GDC-0449
Hedgehog Antagonist GDC-0449
Vismodegib
VISMODEGIB

External Source Codes: 
CAS Registry Number 879085-55-9 (see NLM ChemIDplus info)
FDA UNII Code 25X868M3DS
PDQ Closed Trial Search ID 586417
PDQ Open Trial Search ID 586417 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348949

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For basal cell carcinoma
Chemical_Formula C19H14Cl2N2O3S
code C74038
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Hedgehog_Antagonist_GDC-0449
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74038

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