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Version: 17.06d (Release date: 2017-06-26)
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Gold Sodium Thiomalate (Code C74037)

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Terms & Properties

Preferred Name: Gold Sodium Thiomalate

Definition: The sodium salt of gold thiomalic acid, an organogold compound with antirheumatic and potential antineoplastic activities. Gold sodium thiomalate (GST) appears to inhibit the activity of atypical protein kinase C iota (PKCiota) by forming a cysteinyl-aurothiomalate adduct with the cysteine residue Cys-69 within the PB1 binding domain of PKCiota. This prevents the binding of Par6 (Partitioning defective protein 6) to PKCiota, thereby inhibiting PKCiota-mediated oncogenic signaling, which may result in the inhibition of tumor cell proliferation, the promotion of tumor cell differentiation, and the induction of tumor cell apoptosis. Atypical PKCiota, a serine/threonine kinase overexpressed in numerous cancer cell types, plays an important role in cancer proliferation, invasion, and survival; Par6 is a scaffold protein that facilitates atypical PKC-mediated phosphorylation of cytoplasmic proteins involved in epithelial and neuronal cell polarization.

Display Name: Gold Sodium Thiomalate

Label: Gold Sodium Thiomalate

NCI Thesaurus Code: C74037 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0018034  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aurolate
Aurothiomalate Disodium
Gold Sodium Thiomalate
GOLD SODIUM THIOMALATE
Myochrysine

External Source Codes: 
CAS Registry Number 12244-57-4 (see NLM ChemIDplus info)
FDA UNII Code E4768ZY6GM
ChEBI ID CHEBI:5516 (see ChEBI info)
PDQ Closed Trial Search ID 581226
PDQ Open Trial Search ID 581226 (check for NCI PDQ open clinical trial info)
UMLS CUI C0018034

Other Properties:
     Name Value (qualifiers indented underneath)
code C74037
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Gold_Sodium_Thiomalate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74037

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