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Version: 17.06d (Release date: 2017-06-26)
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Fluciclatide F-18 (Code C74031)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluciclatide F-18

Definition: A radiopharmaceutical compound of a small synthetic cyclic peptide containing an RGD-sequence (Arg-Gly-Asp) labeled with the positron-emitting isotope fluorine F 18 that may be used to selectively image tumor cells and tumor vasculature by PET imaging. The RGD motif of fluciclatide F 18 selectively binds to the alphaVbeta3 integrin receptor, commonly upregulated on the surfaces of tumor cells and endothelial cells of tumor vasculature. This agent may be of use in visualizing and quantifying the development of tumor vascularity in response to antiangiogenic agents.

Display Name: Fluciclatide F-18

Label: Fluciclatide F-18

NCI Thesaurus Code: C74031 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348692  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18F-AH111585
[18F]AH111585
Fluciclatide F-18

External Source Codes: 
PDQ Closed Trial Search ID 683509
PDQ Open Trial Search ID 683509 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348692

Other Properties:
     Name Value (qualifiers indented underneath)
code C74031
Contributing_Source CTRP
Legacy_Concept_Name Fluorine_F_18-RGD_AH111585
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74031

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