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Version: 17.06d (Release date: 2017-06-26)
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Endothelin B Receptor Agonist SPI-1620 (Code C74027)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Endothelin B Receptor Agonist SPI-1620

Definition: A highly selective peptide agonist of the endothelin-B receptor. Endothelin B receptor agonist SPI-1620 binds to endothelin-B receptors on endothelial cells in tumor blood vessels, which, unlike the angioarchitecture of normal blood vessels, are relatively devoid of smooth muscle. This agent may induce a transient, selective increase in blood flow to a tumor, which may result in an increase in the delivery of anticancer agents to the tumor and, so, an increase in anticancer agent efficacy.

Display Name: Endothelin B Receptor Agonist SPI-1620

Label: Endothelin B Receptor Agonist SPI-1620

NCI Thesaurus Code: C74027 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383531  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Endothelin B Receptor Agonist SPI-1620

External Source Codes: 
PDQ Closed Trial Search ID 589519
PDQ Open Trial Search ID 589519 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C74027
Contributing_Source CTRP
Legacy_Concept_Name Endothelin_B_Receptor_Agonist_SPI-1620
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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