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Version: 17.12d (Release date: 2017-12-26)
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Zoptarelin Doxorubicin (Code C74025)

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Terms & Properties

Preferred Name: Zoptarelin Doxorubicin

Definition: A peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R) that is conjugated to the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation.

Display Name: Zoptarelin Doxorubicin

Label: Zoptarelin Doxorubicin

NCI Thesaurus Code: C74025 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0658619  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Doxorubicin-GNRH Agonist Conjugate AEZS-108
Zoptarelin Doxorubicin

External Source Codes: 
PDQ Closed Trial Search ID 583257
PDQ Open Trial Search ID 583257 (check for NCI PDQ open clinical trial info)
UMLS CUI C0658619

Other Properties:
     Name Value (qualifiers indented underneath)
code C74025
Contributing_Source CTRP
Legacy_Concept_Name Doxorubicin-GNRH_Agonist_Conjugate_AEZS-108
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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