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Version: 17.04d (Release date: 2017-04-24)
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Diclofenac Sodium Gel (Code C74024)

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Terms & Properties

Preferred Name: Diclofenac Sodium Gel

Definition: A gel formulation of the sodium salt of diclofenac, a nonsteroidal benzeneacetic acid derivative with analgesic, antipyretic and anti-inflammatory activities. Diclofenac binds to and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid (AA) to pro-inflammatory prostaglandins. This agent may also inhibit lipoxygenases, resulting in the inhibition of pro-inflammatory leukotriene synthesis from AA.

NCI-GLOSS Definition: The gel form of a drug that is used to treat the symptoms of rheumatoid arthritis and is being studied in the prevention and treatment of some types of skin cancer. It blocks substances that cause inflammation and pain. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent.

Display Name: Diclofenac Sodium Gel

Label: Diclofenac Sodium Gel

NCI Thesaurus Code: C74024 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0939478  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Diclofenac Sodium Gel
diclofenac sodium gel
Solaraze
Voltaren gel

External Source Codes: 
PDQ Closed Trial Search ID 585657
PDQ Open Trial Search ID 585657 (check for NCI PDQ open clinical trial info)
UMLS CUI C0939478

Other Properties:
     Name Value (qualifiers indented underneath)
code C74024
Contributing_Source CTRP
Legacy_Concept_Name Diclofenac_Sodium_Gel
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74024

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