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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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CD3/CD28 Costimulated Autologous T-Cells (Code C74017)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: CD3/CD28 Costimulated Autologous T-Cells

Definition: A population of T cells that have been sensitized to vaccine tumor antigen(s) in vivo; collected from the patient; co-stimulated with antibodies to the T-cell cell surface proteins CD3 and CD28 and expanded ex vivo; and then infused into the same patient. CD3, part of the T cell receptor complex, and CD28, a T-cell surface-associated co-stimulatory molecule, are both required for full T-cell activation. Adoptive transfer of CD3/CD28 costimulated vaccine-primed autologous T-cells may induce the production of interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) and associated antitumor effects and a graft-versus-tumor (GVT) response.

Display Name: CD3/CD28 Costimulated Autologous T-Cells

Label: CD3/CD28 Costimulated Autologous T-Cells

NCI Thesaurus Code: C74017 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383502  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CD3/CD28 Costimulated Autologous T-Cells

External Source Codes: 
PDQ Closed Trial Search ID 587501
PDQ Open Trial Search ID 587501 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383502

Other Properties:
     Name Value (qualifiers indented underneath)
code C74017
Contributing_Source CTRP
Legacy_Concept_Name CD3_CD28_Costimulated_Autologous_T-Cells
Semantic_Type Cell

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74017

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