skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Dalotuzumab (Code C74011)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dalotuzumab

Definition: A recombinant humanized monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Dalotuzumab binds to membrane-bound IGF1R, preventing binding of the ligand IGF1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. The activation of IGF1R, a tyrosine kinase and a member of the insulin receptor family, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF1R signaling has been highly implicated in tumorigenesis and metastasis.

NCI-GLOSS Definition: A substance being studied in the treatment of many types of cancer. MK-0646 binds to a protein called insulin-like growth factor receptor (IGFR) on the surface of cells. This may prevent the cells from growing when IGF is present. It may also kill cancer cells. MK-0646 is a type of monoclonal antibody.

Display Name: Dalotuzumab

Label: Dalotuzumab

NCI Thesaurus Code: C74011 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987605  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-IGF-1R Recombinant Monoclonal Antibody MK-0646
anti-IGF1R recombinant monoclonal antibody MK-0646
Dalotuzumab
DALOTUZUMAB
MK-0646

External Source Codes: 
CAS Registry Number 1005389-60-5 (see NLM ChemIDplus info)
FDA UNII Code 6YI1L648RH
PDQ Closed Trial Search ID 489297
PDQ Open Trial Search ID 489297 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987605

Other Properties:
     Name Value (qualifiers indented underneath)
code C74011
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-IGF1R_Recombinant_Monoclonal_Antibody_MK-0646
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74011

Mainbox Bottom