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Version: 17.12d (Release date: 2017-12-26)
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Dalotuzumab (Code C74011)

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Terms & Properties

Preferred Name: Dalotuzumab

Definition: A recombinant humanized monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Dalotuzumab binds to membrane-bound IGF1R, preventing binding of the ligand IGF1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. The activation of IGF1R, a tyrosine kinase and a member of the insulin receptor family, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF1R signaling has been highly implicated in tumorigenesis and metastasis.

NCI-GLOSS Definition: A substance being studied in the treatment of many types of cancer. MK-0646 binds to a protein called insulin-like growth factor receptor (IGFR) on the surface of cells. This may prevent the cells from growing when IGF is present. It may also kill cancer cells. MK-0646 is a type of monoclonal antibody.

Display Name: Dalotuzumab

Label: Dalotuzumab

NCI Thesaurus Code: C74011 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987605  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-IGF-1R Recombinant Monoclonal Antibody MK-0646
anti-IGF1R recombinant monoclonal antibody MK-0646

External Source Codes: 
CAS Registry Number 1005389-60-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 489297
PDQ Open Trial Search ID 489297 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987605

Other Properties:
     Name Value (qualifiers indented underneath)
code C74011
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-IGF1R_Recombinant_Monoclonal_Antibody_MK-0646
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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