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Version: 17.06d (Release date: 2017-06-26)
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Anti-Endoglin Chimeric Monoclonal Antibody TRC105 (Code C74010)

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Terms & Properties

Preferred Name: Anti-Endoglin Chimeric Monoclonal Antibody TRC105

Definition: A human/murine chimeric monoclonal antibody directed against endoglin (CD105) with potential antiangiogenic and antineoplastic activities. Anti-endoglin monoclonal antibody TRC105 binds to endoglin, which may result in inhibition of tumor angiogenesis and decreased tumor cell proliferation. The glycoprotein endoglin is a transforming growth factor beta-1 (TGF beta-1) accessory receptor that is highly expressed on tumor vessel endothelial cells and appears to be essential for angiogenesis.

Display Name: Anti-Endoglin Chimeric Monoclonal Antibody TRC105

Label: Anti-Endoglin Chimeric Monoclonal Antibody TRC105

NCI Thesaurus Code: C74010 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346810  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-Endoglin Chimeric Monoclonal Antibody TRC105
TRC105

External Source Codes: 
PDQ Closed Trial Search ID 584952
PDQ Open Trial Search ID 584952 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346810

Other Properties:
     Name Value (qualifiers indented underneath)
code C74010
Contributing_Source CTRP
Legacy_Concept_Name Anti-Endoglin_Chimeric_Monoclonal_Antibody_TRC105
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74010

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