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Version: 16.11d (Release date: 2016-11-28)
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CD40 Agonist Monoclonal Antibody CP-870,893 (Code C74008)

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Terms & Properties

Preferred Name: CD40 Agonist Monoclonal Antibody CP-870,893

Definition: A fully human monoclonal antibody (mAb) agonist of the cell surface receptor CD40 with potential immunostimulatory and antineoplastic activities. Similar to the CD40 ligand (CD40L or CD154), CD40 agonist monoclonal antibody CP-870,893 binds to CD40 on a variety of immune cell types, triggering the cellular proliferation and activation of antigen-presenting cells (APCs), activating B cells and T cells, and enhancing the immune response; in addition, this agent may activate CD40 present on the surfaces of some solid tumor cells, resulting in apoptosis and decreased tumor growth. CD40, a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells, many B-cell malignancies, and some solid tumors, mediating both indirect tumor cell killing through the activation of the immune system and direct tumor cell apoptosis.

Display Name: CD40 Agonist Monoclonal Antibody CP-870,893

Label: CD40 Agonist Monoclonal Antibody CP-870,893

NCI Thesaurus Code: C74008 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1869412  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CD40 Agonist Monoclonal Antibody CP-870,893
CP-870,893

External Source Codes: 
PDQ Closed Trial Search ID 588974
PDQ Open Trial Search ID 588974 (check for NCI PDQ open clinical trial info)
UMLS CUI C1869412

Other Properties:
Name Value (qualifiers indented underneath)
code C74008
Contributing_Source CTRP
Legacy_Concept_Name Anti-CD40_Monoclonal_Antibody_CP-870_893
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74008

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