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Version: 17.06d (Release date: 2017-06-26)
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Daratumumab (Code C74007)

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Terms & Properties

Preferred Name: Daratumumab

Definition: A fully human monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. The binding of anti-CD38 monoclonal antibody to natural killer (NK) cells mimics the normal CD38-CD31 interaction on the NK cell surface. CD38 is also present on multiple myeloma (MM) cells and plasma leukemia cells; this agent may preferentially bind these cells, triggering antitumoral antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). CD38, a cell surface glycoprotein, is present on various immune cells and has been shown to regulate the cytotoxic response of activated NK cells.

Display Name: Daratumumab

Label: Daratumumab

NCI Thesaurus Code: C74007 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346801  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD38 Monoclonal Antibody
Daratumumab
DARATUMUMAB
Darzalex
HuMax-CD38
JNJ-54767414

External Source Codes: 
CAS Registry Number 945721-28-8 (see NLM ChemIDplus info)
FDA UNII Code 4Z63YK6E0E
PDQ Closed Trial Search ID 583564
PDQ Open Trial Search ID 583564 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346801

Other Properties:
     Name Value (qualifiers indented underneath)
code C74007
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-CD38_Monoclonal_Antibody
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74007

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