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Version: 17.06d (Release date: 2017-06-26)
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Otlertuzumab (Code C74006)

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Terms & Properties

Preferred Name: Otlertuzumab

Definition: A recombinant single-chain polypeptide engineered to exhibit the full binding and activity of an anti-CD37 monoclonal antibody with potential immunostimulatory and antineoplastic activities. Otlertuzumab binds to CD37 on B-cells, which may result in antibody-dependent cell-mediated cytotoxicity (ADCC) and apoptosis. CD37 is a transmembrane glycoprotein expressed at high-levels on B cells and to a lesser extent on T cells and myeloid cells. This agent may have a longer half-life in vivo than conventional monoclonal antibodies.

Display Name: Otlertuzumab

Label: Otlertuzumab

NCI Thesaurus Code: C74006 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346800  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Otlertuzumab
TRU-016

External Source Codes: 
PDQ Closed Trial Search ID 589521
PDQ Open Trial Search ID 589521 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346800

Other Properties:
     Name Value (qualifiers indented underneath)
code C74006
Contributing_Source CTRP
Legacy_Concept_Name Anti-CD37_Single-Chain_Polypeptide_TRU-016
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74006

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