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Version: 17.06d (Release date: 2017-06-26)
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Anti-CD3 Immunotoxin A-dmDT390-bisFv(UCHT1) (Code C74004)

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Terms & Properties

Preferred Name: Anti-CD3 Immunotoxin A-dmDT390-bisFv(UCHT1)

Definition: A bivalent recombinant fusion protein immunotoxin derived from the anti-CD3 monoclonal antibody UCHT1 with potential antineoplastic activity. Anti-CD3 immunotoxin A-dmDT390-bisFv(UCHT1) consists of 1-390 amino acid residues of chain A diphtheria toxin (DT) joined via a spacer to the Fv fragment of UCHT1, which is connected to a second UCHT1 Fv fragment via a disulfide bond (hence the "bisFv" designation); the addition of the second Fv fragment overcomes the steric hindrance of immunotoxin binding due to the large N-terminal DT domain. Once inside target T cells, the DT moiety catalyzes the transfer of the ADP-ribose moiety of NAD to diphthamide, a posttranslationally modified histidine residue found in elongation factor 2 (EF-2); inactivation of EF-2, disruption of polypeptide chain elongation, and cell death ensue. CD3 is a complex of five cell-surface polypeptides associated with the T cell receptor (TCR) complex.

Display Name: Anti-CD3 Immunotoxin A-dmDT390-bisFv(UCHT1)

Label: Anti-CD3 Immunotoxin A-dmDT390-bisFv(UCHT1)

NCI Thesaurus Code: C74004 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383887  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD3 Immunotoxin A-dmDT390-bisFv(UCHT1)

External Source Codes: 
PDQ Closed Trial Search ID 588895
PDQ Open Trial Search ID 588895 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C74004
Contributing_Source CTRP
Legacy_Concept_Name Anti-CD3_Immunotoxin_A-dmDT390-bisFv_UCHT1
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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