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Version: 17.06d (Release date: 2017-06-26)
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Fluciclovine F18 (Code C74002)

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Terms & Properties

Preferred Name: Fluciclovine F18

Definition: A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use. Similar to most amino acids, fluciclovine F18 appears to enter cells through the energy-independent L-type amino acid transporter (LAT) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occurring amino acids, this non-natural amino acid-analogue radiotracer is not metabolized. Accordingly, fluciclovine F18 accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (PET).

Display Name: Fluciclovine F18

Label: Fluciclovine F18

NCI Thesaurus Code: C74002 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1311253  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic Acid
Anti-1-Amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid
Anti-[18F] FACBC
Fluciclovine (18F)
Fluciclovine F18
GE-148 (18F)
GE-148 F-18

External Source Codes: 
CAS Registry Number 222727-39-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 581382
PDQ Open Trial Search ID 581382 (check for NCI PDQ open clinical trial info)
UMLS CUI C1311253

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C5H8FNO2
code C74002
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-1-Amino-3-Fluorocyclobutane-1-Carboxylic_Acid
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  


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