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Version: 17.06d (Release date: 2017-06-26)
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Fluciclovine F18 (Code C74002)

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Terms & Properties

Preferred Name: Fluciclovine F18

Definition: A radiotracer containing a synthetic amino acid analogue of L-leucine radiolabeled with fluorine F 18 with potential diagnostic imaging use. Similar to most amino acids, fluciclovine F18 appears to enter cells through the energy-independent L-type amino acid transporter (LAT) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occurring amino acids, this non-natural amino acid-analogue radiotracer is not metabolized. Accordingly, fluciclovine F18 accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (PET).

Display Name: Fluciclovine F18

Label: Fluciclovine F18

NCI Thesaurus Code: C74002 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1311253  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(18F)Fluciclovine
(18F)GE-148
(1R,3R)-1-Amino-3(18f)fluorocyclobutane-1-carboxylic Acid
18F-Fluciclovine
[18F]FACBC
Anti-(18f)FABC
Anti-1-Amino-3-[18F]Fluorocyclobutane-1-Carboxylic Acid
Anti-[18F] FACBC
Axumin
Fluciclovine (18F)
FLUCICLOVINE F-18
Fluciclovine F18
GE-148 (18F)
GE-148 F-18

External Source Codes: 
CAS Registry Number 222727-39-1 (see NLM ChemIDplus info)
FDA UNII Code 38R1Q0L1ZE
PDQ Closed Trial Search ID 581382
PDQ Open Trial Search ID 581382 (check for NCI PDQ open clinical trial info)
UMLS CUI C1311253

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C5H8FNO2
code C74002
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-1-Amino-3-Fluorocyclobutane-1-Carboxylic_Acid
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74002

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