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Version: 16.11d (Release date: 2016-11-28)
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Tiomolibdate Diammonium (Code C74001)

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Terms & Properties

Preferred Name: Tiomolibdate Diammonium

Definition: An ammonium salt with potential antiangiogenic and antitumor activities. Tetrathiomolybdate has been found to deplete systemic copper reserves through an unknown mechanism. This agent has been shown to inhibit the activities of cuproenzymes, including superoxide dismutase 1 (SOD1) and cytochrome c oxidase (COX), which may contribute to its antiangiogenic and antitumor effects.

NCI-GLOSS Definition: A substance being studied in the treatment of many types of cancer. Ammonium tetrathiomolybdate removes extra copper from the body. Removing the copper may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. Ammonium tetrathiomolybdate is a type of chelating agent and a type of antiangiogenesis agent.

Label: Tiomolibdate Diammonium

NCI Thesaurus Code: C74001 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0076339  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ammonium Molybdenum Sulfide
Ammonium Tetrathiomolybdate
ammonium tetrathiomolybdate
ATTM
Coprexa
Diammonium Tetrathiomolybdate
Molybdate(2-), Tetrathioxo-, Ammonium (1:2), (T-4)-
Molybdate(2-), Tetrathioxo-, Diammonium, (T-4)-
TIOMOLIBDATE DIAMMONIUM
Tiomolibdate Diammonium

External Source Codes: 
CAS Registry Number 15060-55-6 (see NLM ChemIDplus info)
FDA UNII Code 4V6I63LW1E
NSC Code 286644 (see NCI DTP info)
NSC Code 714598 (see NCI DTP info)
PDQ Closed Trial Search ID 467218
PDQ Open Trial Search ID 467218 (check for NCI PDQ open clinical trial info)
UMLS CUI C0076339

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula MoS4.2H4N
code C74001
Contributing_Source FDA
Legacy_Concept_Name Ammonium_Tetrathiomolybdate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C74001

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