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Version: 16.11d (Release date: 2016-11-28)
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Aglatimagene Besadenovec (Code C73996)

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Terms & Properties

Preferred Name: Aglatimagene Besadenovec

Definition: An adenoviral vector engineered to express the herpes simplex virus thymidine kinase (HSV-tk) gene, which, when administered in conjunction with a synthetic acyclic guanosine analogue, possesses potential antineoplastic activity. Aglatimagene besadenovec is transduced into tumor cells, sensitizing tumor cells that overexpress HSV-tk to synthetic acyclic guanosine analogues. Subsequently, a low dose of a synthetic acyclic guanosine analogue such as valacyclovir (VCV) or ganciclovir (GCV) is given, which may preferentially kill tumor cells containing the adenoviral vector and overexpressing HSV-tk. Release of tumor-associated antigens (TAAs) by dying tumor cells may then stimulate an antitumor cytotoxic T lymphocyte (CTL) response.

Display Name: Aglatimagene Besadenovec

Label: Aglatimagene Besadenovec

NCI Thesaurus Code: C73996 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383459  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ADV-tk
Aglatimagene Besadenovec
AGLATIMAGENE BESADENOVEC
GliAtak
ProstAtak
Virafir

External Source Codes: 
CAS Registry Number 1621271-62-2 (see NLM ChemIDplus info)
FDA UNII Code 5Z72SSS34W
PDQ Closed Trial Search ID 581584
PDQ Open Trial Search ID 581584 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383459

Other Properties:
Name Value (qualifiers indented underneath)
code C73996
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Adenoviral_Vector_Encoding_HSV_Thymidine_Kinase
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C73996

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