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Version: 17.06d (Release date: 2017-06-26)
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Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells (Code C73995)

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Terms & Properties

Preferred Name: Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells

Definition: Autologous dendritic cells (DCs) transduced with the replication-deficient adenoviral vector Ad5F53 encoding the Epstein-Barr virus (EBV) transmembrane latent membrane proteins 1 and 2 (LMP1/LMP2) with potential immunostimulatory activity. Vaccination with Ad5F35-LMP1/LMP2-transduced autologous dendritic cells may stimulate a specific cytotoxic T-lymphocyte (CTL) response against LMP1- and LMP2-expressing tumor positive cells, resulting in tumor cell lysis and inhibition of tumor cell proliferation. LMP1 and LMP2 are expressed in various malignancies including nasopharyngeal cancer and EBV-positive Hodgkins disease.

Label: Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells

NCI Thesaurus Code: C73995 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL383744  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad5F35-LMP1/LMP2-Transduced Autologous Dendritic Cells

External Source Codes: 
PDQ Closed Trial Search ID 582896
PDQ Open Trial Search ID 582896 (check for NCI PDQ open clinical trial info)
NCI META CUI CL383744

Other Properties:
     Name Value (qualifiers indented underneath)
code C73995
Legacy_Concept_Name Ad5F35-LMP1_LMP2-Transduced_Autologous_Dendritic_Cells
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C73995

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