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Version: 16.11d (Release date: 2016-11-28)
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Serine Protease Inhibitor WX-671 (Code C73985)

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Terms & Properties

Preferred Name: Serine Protease Inhibitor WX-671

Definition: An orally bioavailable, 3-amidinophenylalanine-derived, second generation serine protease inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system with potential antineoplastic and antimetastatic activities. After oral administration, serine protease inhibitor WX-671 is converted to the active N alpha-(2,4,6-triisopropylphenylsulfonyl)-3-amidino-(L)-phenylalanine-4-ethoxycarbonylpiperazide (WX-UK1), which inhibits several serine proteases, particularly uPA; inhibition of uPA may result in the inhibition of tumor growth and metastasis. uPA is a serine protease involved in degradation of the extracellular matrix and tumor cell migration and proliferation.

NCI-GLOSS Definition: A substance being studied in the treatment of several types of cancer. It blocks the action of certain enzymes, and it may help keep cancer cells from growing and spreading. It is a type of serine protease inhibitor.

Display Name: Serine Protease Inhibitor WX-671

Label: Serine Protease Inhibitor WX-671

NCI Thesaurus Code: C73985 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348191  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Serine Protease Inhibitor WX-671
WX-671

External Source Codes: 
PDQ Closed Trial Search ID 557106
PDQ Open Trial Search ID 557106 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348191

Other Properties:
Name Value (qualifiers indented underneath)
code C73985
Contributing_Source CTRP
Legacy_Concept_Name Serine_Protease_Inhibitor_WX-671
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C73985

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