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Version: 17.06d (Release date: 2017-06-26)
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Parecoxib Sodium (Code C73831)

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Terms & Properties

Preferred Name: Parecoxib Sodium

Definition: A water-soluble, injectable sodium salt form of parecoxib, an amide prodrug of the cyclooxygenase II (COX-2) selective, non-steroidal anti-inflammatory drug (NSAID) valdecoxib, with anti-inflammatory, analgesic, and antipyretic activities. Upon intravenous or intramuscular administration, parecoxib is hydrolyzed by hepatic carboxyesterases to its active form, valdecoxib. Valdecoxib selectively binds to and inhibits COX-2. This prevents the conversion of arachidonic acid into prostaglandins, which are involved in the regulation of pain, inflammation, and fever. This NSAID does not inhibit COX-1 at therapeutic concentrations and, therefore, does not interfere with blood coagulation.

Label: Parecoxib Sodium

NCI Thesaurus Code: C73831 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0915144  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Parecoxib Sodium
Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)-, Sodium Salt

External Source Codes: 
CAS Registry Number 197502-82-2 (see NLM ChemIDplus info)
CAS Registry Number 198470-85-8 (see NLM ChemIDplus info)
FDA UNII Code EB87433V6F
PDQ Closed Trial Search ID 753381
PDQ Open Trial Search ID 753381 (check for NCI PDQ open clinical trial info)
UMLS CUI C0915144

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H17N2O4S.Na
code C73831
Contributing_Source FDA
Legacy_Concept_Name Parecoxib_Sodium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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