|Varenicline (Code C73609)|
|Terms & Properties|
Preferred Name: Varenicline
Definition: A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself.
NCI-GLOSS Definition: A drug used to help people stop smoking by acting the same way nicotine acts in the brain. It is a type of nicotine receptor partial agonist.
Display Name: Varenicline
NCI Metathesaurus Link: C1569608 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||249296-44-4 (see NLM ChemIDplus info)|
|FDA UNII Code||W6HS99O8ZO|
|PDQ Closed Trial Search ID||584706|
|PDQ Open Trial Search ID||584706 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|