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Version: 17.06d (Release date: 2017-06-26)
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Varenicline (Code C73609)

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Terms & Properties

Preferred Name: Varenicline

Definition: A partial agonist of the nicotinic acetylcholine receptor (nAChR) subtype alpha4beta2. Nicotine stimulation of central alpha4beta2 nAChRs located at presynaptic terminals in the nucleus accumbens causes the release of the neurotransmitter dopamine, which may be associated with the experience of pleasure; nicotine addiction constitutes a physiologic dependence related to this dopaminergic reward system. As an AChR partial agonist, varenicline attenuates the craving and withdrawal symptoms that occur with abstinence from nicotine but is not habit-forming itself.

NCI-GLOSS Definition: A drug used to help people stop smoking by acting the same way nicotine acts in the brain. It is a type of nicotine receptor partial agonist.

Display Name: Varenicline

Label: Varenicline

NCI Thesaurus Code: C73609 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1569608  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine (2R,3R)-2,3-dihydroxybutqanedioate

External Source Codes: 
CAS Registry Number 249296-44-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 584706
PDQ Open Trial Search ID 584706 (check for NCI PDQ open clinical trial info)
UMLS CUI C1569608

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H13N3
code C73609
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Varenicline
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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