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Version: 16.11d (Release date: 2016-11-28)
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Sodium Dichloroacetate (Code C73591)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sodium Dichloroacetate

Definition: The sodium salt of dichloroacetic acid with potential antineoplastic activity. Dichloroacetate ion inhibits pyruvate dehydrogenase kinase, resulting in the inhibition of glycolysis and a decrease in lactate production. This agent may stimulate apoptosis in cancer cells by restoring normal mitochondrial-induced apoptotic signaling.

Display Name: Sodium Dichloroacetate

Label: Sodium Dichloroacetate

NCI Thesaurus Code: C73591 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0037501  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CPC 211
Dichloroacetic Acid, Sodium Salt
Sodium Dichloroacetate
SODIUM DICHLOROACETATE

External Source Codes: 
CAS Registry Number 2156-56-1 (see NLM ChemIDplus info)
FDA UNII Code 42932X67B5
PDQ Closed Trial Search ID 582893
PDQ Open Trial Search ID 582893 (check for NCI PDQ open clinical trial info)
UMLS CUI C0037501

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C2HCl2O2.Na
code C73591
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Sodium_Dichloroacetate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C73591

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