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Version: 17.06d (Release date: 2017-06-26)
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Pentoxifylline (Code C733)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pentoxifylline

Definition: A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses.

NCI-GLOSS Definition: A drug used to prevent blood clotting and as a treatment that may help decrease weight loss in people with cancer.

Display Name: Pentoxifylline

Label: Pentoxifylline

NCI Thesaurus Code: C733 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0030899  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
Oxpentifylline
Pentoxifylline
pentoxifylline
PENTOXIFYLLINE
Pentoxyphylline
PTX
Trental

External Source Codes: 
CAS Registry Number 6493-05-6 (see NLM ChemIDplus info)
FDA UNII Code SD6QCT3TSU
NSC Code 637086 (see NCI DTP info)
PDQ Closed Trial Search ID 41432
PDQ Open Trial Search ID 41432 (check for NCI PDQ open clinical trial info)
UMLS CUI C0030899

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H18N4O3
code C733
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pentoxifylline
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C733

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