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Version: 16.10e (Release date: 2016-10-31)
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Pentostatin (Code C732)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pentostatin

Definition: A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04)

NCI-GLOSS Definition: The active ingredient in a drug that is used to treat hairy cell leukemia and is being studied in the treatment of other types of cancer. Pentostatin blocks a protein needed for cell growth and may kill cancer cells. It is made by a bacterium. It is a type of adenosine deaminase inhibitor.

Display Name: Pentostatin

Label: Pentostatin

NCI Thesaurus Code: C732 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0030896  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
(R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
2'-Deoxycoformycin
CI-825
Co-Vidarabine
Co-vidarabine
Covidarabine
DCF
Deoxycoformycin
Nipent
PD-81565
Pentostatin
PENTOSTATIN
pentostatin
Pentostatine

External Source Codes: 
CAS Registry Number 53910-25-1 (see NLM ChemIDplus info)
CAS Registry Number 63677-95-2 (see NLM ChemIDplus info)
FDA UNII Code 395575MZO7
NSC Code 218321 (see NCI DTP info)
NSC Code 247520 (see NCI DTP info)
PDQ Closed Trial Search ID 39210
PDQ Open Trial Search ID 39210 (check for NCI PDQ open clinical trial info)
UMLS CUI C0030896

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chronic lymphocytic leukemia; Cutaneous t-cell lymphoma; Hairy cell leukemia
Chemical_Formula C11H16N4O4
code C732
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pentostatin
Semantic_Type Antibiotic
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C732

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