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Version: 17.06d (Release date: 2017-06-26)
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Pentamidine (Code C731)

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Terms & Properties

Preferred Name: Pentamidine

Definition: A synthetic derivative of amidine with antiprotozoal and antifungal activities. Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04)

NCI-GLOSS Definition: The active ingredient in a drug used to treat infections caused by certain microorganisms. It is also being studied in the treatment of melanoma. It prevents DNA from being copied and may kill cancer cells. It is a type of antifungal agent, a type of antiprotozoal agent, and a type of PRL phosphatase inhibitor.

Display Name: Pentamidine

Label: Pentamidine

NCI Thesaurus Code: C731 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0030863  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Aerosolized Pentamadine

External Source Codes: 
CAS Registry Number 100-33-4 (see NLM ChemIDplus info)
ChEBI ID CHEBI:45081 (see ChEBI info)
NSC Code 9921 (see NCI DTP info)
PDQ Closed Trial Search ID 40324
PDQ Open Trial Search ID 40324 (check for NCI PDQ open clinical trial info)
UMLS CUI C0030863

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H24N4O2
code C731
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pentamidine
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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