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Version: 17.06d (Release date: 2017-06-26)
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Penicillamine (Code C729)

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Terms & Properties

Preferred Name: Penicillamine

Definition: A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04)

NCI-GLOSS Definition: A drug that removes copper from the body and is used to treat diseases in which there is an excess of this metal. It is also being studied as a possible angiogenesis inhibitor in brain tumors.

Label: Penicillamine

NCI Thesaurus Code: C729 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0030817  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
.beta.,.beta.-Dimethylcysteine
3-Mercapto-D-valine
Alpha-amino-beta-methyl-beta-mercaptobutyric Acid
Atamir
Beta,Beta-dimethylcysteine
Beta-thiovaline
Cuprenil
Cuprimine
Cupripen
D-Mercaptovaline
D-Penicillamine
Depamine
Depen
Distamine
Kelatin
Mercaptyl
Metalcaptase
Pendramine
Penicillamine
penicillamine
PENICILLAMINE
Perdolat
Sufortan
Trolovol

External Source Codes: 
CAS Registry Number 52-67-5 (see NLM ChemIDplus info)
FDA UNII Code GNN1DV99GX
ChEBI ID CHEBI:7959 (see ChEBI info)
NSC Code 81549 (see NCI DTP info)
PDQ Closed Trial Search ID 42546
PDQ Open Trial Search ID 42546 (check for NCI PDQ open clinical trial info)
UMLS CUI C0030817

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Wilsons disease; heavy metal intoxication; cystinuria; rheumatoid arthritis; primary biliary cirrhosis; Feltys syndrome; rheumatoid vasculitis
Chemical_Formula C5H11NO2S
code C729
Contributing_Source FDA
Legacy_Concept_Name Penicillamine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C729

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