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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Tigecycline (Code C72865)

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Terms & Properties

Preferred Name: Tigecycline

Definition: A broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the incorporation of amino acid residues into the elongating peptide chain, inhibiting protein synthesis and eventually bacterial cell growth.

Label: Tigecycline

NCI Thesaurus Code: C72865 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1260298  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 220620-09-7 (see NLM ChemIDplus info)
ChEBI ID CHEBI:149836 (see ChEBI info)
UMLS CUI C1260298

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Community-Acquired Bacterial Pneumonia
Chemical_Formula C29H39N5O8
code C72865
Contributing_Source FDA
Legacy_Concept_Name Tigecycline
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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