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Version: 17.12d (Release date: 2017-12-26)
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Fesoterodine Fumarate (Code C72779)

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Terms & Properties

Preferred Name: Fesoterodine Fumarate

Definition: The fumarate salt form of fesoterodine, a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo into its active metabolite 5-hydroxy methyl tolterodine, which binds and inhibits muscarinic receptors on the bladder detrusor muscle, thereby preventing bladder contractions or spasms caused by acetylcholine. This results in the relaxation of bladder smooth muscle and greater bladder capacity, in addition to a reduction in involuntary muscle contractions and involuntary loss of urine. The active metabolite does not interact with alpha-adrenergic, serotonergic, histaminergic and excitatory amino acid receptors and is eliminated via renal excretion.

Label: Fesoterodine Fumarate

NCI Thesaurus Code: C72779 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2343854  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-((1R)-3-(Diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl Isobutyrate
Fesoterodine Fumarate
SPM 8272
SPM 907

External Source Codes: 
CAS Registry Number 286930-03-8 (see NLM ChemIDplus info)
FDA UNII Code EOS72165S7
PDQ Closed Trial Search ID 738879
PDQ Open Trial Search ID 738879 (check for NCI PDQ open clinical trial info)
UMLS CUI C2343854

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H37NO3.C4H4O4
code C72779
Contributing_Source FDA
Legacy_Concept_Name Fesoterodine_Fumarate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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