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Version: 17.06d (Release date: 2017-06-26)
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Dexmedetomidine Hydrochloride (Code C72738)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dexmedetomidine Hydrochloride

Definition: The hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis.

Display Name: Dexmedetomidine Hydrochloride

Label: Dexmedetomidine Hydrochloride

NCI Thesaurus Code: C72738 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0752310  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dexmedetomidine Hydrochloride
DEXMEDETOMIDINE HYDROCHLORIDE
Precedex

External Source Codes: 
CAS Registry Number 145108-58-3 (see NLM ChemIDplus info)
FDA UNII Code 1018WH7F9I
ChEBI ID CHEBI:31472 (see ChEBI info)
PDQ Closed Trial Search ID 632933
PDQ Open Trial Search ID 632933 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 9227530 (see PubMed Primary Reference info)
UMLS CUI C0752310

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H16N2.HCl
code C72738
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Dexmedetomidine_Hydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C72738

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