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Version: 17.06d (Release date: 2017-06-26)
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Denibulin Hydrochloride (Code C72736)

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Terms & Properties

Preferred Name: Denibulin Hydrochloride

Definition: The hydrochloride salt of denibulin, a small molecular vascular disrupting agent, with potential antimitotic and antineoplastic activities. Denibulin selectively targets and reversibly binds to the colchicine-binding site on tubulin and inhibits microtubule assembly. This results in the disruption of the cytoskeleton of tumor endothelial cells, ultimately leading to cell cycle arrest, blockage of cell division and apoptosis. This causes inadequate blood flow to the tumor and eventually leads to a decrease in tumor cell proliferation., a small molecule vascular disrupting agent (VDA), with potential antimitotic and antineoplastic activity. Denibulin selectively targets and reversibly binds to the colchicine-binding site on tubulin and inhibits microtubule assembly. This results in the disruption of the cytoskeleton of tumor endothelial cells (EC), ultimately leading to cell cycle arrest, blockage of cell division and apoptosis. This causes inadequate blood flow to the tumor and eventually leads to a decrease in tumor cell proliferation.

Display Name: Denibulin Hydrochloride

Label: Denibulin Hydrochloride

NCI Thesaurus Code: C72736 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1679364  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Denibulin Hydrochloride
DENIBULIN HYDROCHLORIDE
MN-029

External Source Codes: 
CAS Registry Number 779356-64-8 (see NLM ChemIDplus info)
FDA UNII Code 0U575HR16Q
PDQ Closed Trial Search ID 746028
PDQ Open Trial Search ID 746028 (check for NCI PDQ open clinical trial info)
UMLS CUI C1679364

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C18H19N5O3S.HCl
code C72736
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Denibulin_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C72736

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